休斯顿大学科研小组成员、生物与生化学院助理教授罗曼（Gregg W. Roman）在接受《财经》采访时表示，鉴于褪黑素的这一副作用，建议消费者应该谨遵医嘱，不要轻易服用褪黑素或者含有这种激素成分的保健品。（财经）
原始出处:
Science 16 November 2007:
Vol. 318. no. 5853, pp. 1144 - 1146
DOI: 10.1126/science.1148564
Melatonin Suppresses Nighttime Memory Formation in Zebrafish
Oliver Rawashdeh, Nancy Hernandez de Borsetti, Gregg Roman,* Gregory M. Cahill
Memory processes are modulated by the biological clock, although the mechanisms are unknown. Here, we report that in the diurnal zebrafish both learning and memory formation of an operant conditioning paradigm occur better during the day than during the night. Melatonin treatment during the day mimics the nighttime suppression of memory formation. Training in constant light improves nighttime memory formation while reducing endogenous melatonin concentrations. Treatment with melatonin receptor antagonists at night dramatically improves memory. Pinealectomy also significantly improves nighttime memory formation. We adduce that melatonin is both sufficient and necessary for poor memory formation during the night.
Department of Biology and Biochemistry, University of Houston, 369 Science and Research II, Houston, TX 77204–5001, USA.
