论文
论文标题:Genetic ancestry effects on the response to viral infection are pervasive but cell type specific
作者:Haley E. Randolph, Jessica K. Fiege, Beth K. Thielen, Clayton K. Mickelson, Mari Shiratori, João Barroso-Batista, Ryan A. Langlois, Luis B. Barreiro
期刊:Science
发表时间:2021/11/26
数字识别码:10.1126/science.abg0928
摘要:Humans differ in their susceptibility to infectious disease, partly owing to variation in the immune response after infection. We used single-cell RNA sequencing to quantify variation in the response to influenza infection in peripheral blood mononuclear cells from European- and African-ancestry males. Genetic ancestry effects are common but highly cell type specific. Higher levels of European ancestry are associated with increased type I interferon pathway activity in early infection, which predicts reduced viral titers at later time points. Substantial population-associated variation is explained by cis-expression quantitative trait loci that are differentiated by genetic ancestry. Furthermore, genetic ancestry–associated genes are enriched among genes correlated with COVID-19 disease severity, suggesting that the early immune response contributes to ancestry-associated differences for multiple viral infection outcomes.
所属学科:
基因组学
免疫学
美国芝加哥大学(University of Chicago)的一项新研究发现,欧洲和非洲裔的男性个体之间对流感的免疫激活途径存在差异,导致该差异的基因会影响新冠的患病严重程度。研究人员从欧洲和非洲血统的男性身上收集了外周血单核细胞(PBMC,一种多样化的免疫细胞)。通过将这些细胞暴露于流感中,该团队检查了各种免疫细胞类型的基因特征,并探究了流感病毒如何影响每种细胞类型的基因表达。结果显示,相比非洲裔,欧洲裔个体早期感染中 I 型干扰素活性增加,可抑制病毒复制。研究人员指出,外周血单核细胞抵抗病毒的能力差异与环境和生活方式的差异也可能共同影响免疫能力。这一结果可能帮助解释不同族裔人群感染新冠后的病情差异。该研究21- 11 月 26 日发表于《科学》(Science)。(University of Chicago)