论文一 https://www.science.org/doi/10.1126/science.abp8202
论文二 https://www.science.org/doi/10.1126/science.abp9262
论文三 https://www.science.org/doi/10.1126/science.abp9444
论文四 https://www.science.org/doi/10.1126/science.abp9186
论文标题:Molecular diversity and evolution of neuron types in the amniote brain
作者:David Hain, Tatiana Gallego-Flores, Michaela Klinkman, Angeles Macias, Elena Ciirdaeva, Anja Arends, et al.
期刊:Science
发表时间:2022/09/02
数字识别码:10.1126/science.abp8202
摘要:The existence of evolutionarily conserved regions in the vertebrate brain is well established. The rules and constraints underlying the evolution of neuron types, however, remain poorly understood. To compare neuron types across brain regions and species, we generated a cell type atlas of the brain of a bearded dragon and compared it with mouse datasets. Conserved classes of neurons could be identified from the expression of hundreds of genes, including homeodomain-type transcription factors and genes involved in connectivity. Within these classes, however, there are both conserved and divergent neuron types, precluding a simple categorization of the brain into ancestral and novel areas. In the thalamus, neuronal diversification correlates with the evolution of the cortex, suggesting that developmental origin and circuit allocation are drivers of neuronal identity and evolution.
参考资料:
[1] David Hain et al., Molecular diversity and evolution of neuron types in the amniote brain. Science (2022) DOI: 10.1126/science.abp8202
[2] Katharina Lust et al., Single-cell analyses of axolotl telencephalon organization, neurogenesis, and regeneration. Science (2022) DOI: 10.1126/science.abp9262
[3] Xiaoyu Wei et al, Single-cell Stereo-seq reveals induced progenitor cells involved in axolotl brain regeneration, Science (2022). DOI: 10.1126/science.abp9444
[4] Jamie Woych et al, Cell-type profiling in salamanders identifies innovations in vertebrate forebrain evolution, Science (2022). DOI: 10.1126/science.abp9186
[5] Dylan Z. Faltine-Gonzalez and Justus M. Kebschull. A mosaic of new and old cell types, Science (2022). DOI: 10.1126/science.add9465
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