Nature:科学家发现负责机体对脂肪偏好的脑-肠回路。 脂肪偏好的肠脑回路。 脂肪-肠道内壁的上皮细胞-迷走神经元-大脑。本文是糖脂肪-营养-生存进化关联的基础科学研究论文。
(Baidu Translation: )
No wonder it's so hard to lose weight! New discovery in Nature: Addiction to sugar and fat requires both gut and brain to "carry the pot"
Nature: Scientists found the brain gut circuit responsible for the body's preference for fat. The gut brain circuit of fat preference. Fat - epithelial cells of intestinal lining - vagal nerve element - brain. This paper is a basic scientific research paper on the evolutionary relationship between sugar, fat, nutrition and survival.
(百度翻訳: )
道理でダイエットがこんなに難しいのも無理はない!『ネイチャー』新発見:砂糖と脂肪に癖がつき、腸も脳も「背鍋」になる
Nature:科学者は機体の脂肪に対する好みを担当する脳-腸回路を発見した。脂肪選好の腸脳回路。脂肪−腸内壁の上皮細胞−迷走ニューロン−脳。本文は糖脂肪-栄養-生存進化関連の基礎科学研究論文である。
学术经纬
2022/09/14
论文
论文标题:Gut-Brain Circuits for Fat Preference
作者:Mengtong Li, Hwei-Ee Tan, Zhengyuan Lu, Katherine S. Tsang, Ashley J. Chung & Charles S. Zuker
期刊:Nature
发表时间:2022/09/07
数字识别码:10.1038/s41586-022-05266-z
摘要:The perception of fat evokes strong appetitive and consummatory responses1. Here we show that fat stimuli can induce behavioural attraction even in the absence of a functional taste system2,3. We demonstrate that fat acts post-ingestively via the gut-brain axis to drive preference for fat. Using single-cell data, we identified the vagal neurons responding to intestinal delivery of fat, and showed that genetic silencing of this gut-to-brain circuit abolished the development of fat preference. Next, we compared the gut-to-brain pathways driving preference for fat versus sugar4, and uncovered two parallel systems, one functioning as a general sensor of essential nutrients, responding to intestinal stimulation with sugar, fat and amino acids, while the other is activated only by fat stimuli. Lastly, we engineered animals lacking candidate receptors detecting the presence of intestinal fat, and validated their role as the mediators of gut-to-brain fat-evoked responses. Together, these findings revealed distinct cells and receptors using the gut-brain axis as a fundamental conduit for the development of fat preference.