Nat:儿童和成人对 SARS-CoV-2 局部和全身反应 毒激年积

顾汉现

儿童和成人对 SARS-CoV-2 感染的局部和全身反应  毒力等反应年龄积累  
成年人中细胞毒性T细胞和干扰素刺激的亚群显著增加。

领研网

2022/02/21

论文
论文标题：Local and systemic responses to SARS-CoV-2 infection in children and adults
作者：Yoshida, Masahiro, Worlock, Kaylee B., Huang, Ni, Lindeboom, Rik G. H., Butler, Colin R., Kumasaka, Natsuhiko, Dominguez Conde, Cecilia, Mamanova, Lira, Bolt, Liam, Richardson, Laura, Polanski, Krzysztof, Madissoon, Elo, Barnes, Josephine L., Allen-Hyttinen, Jessica, Kilich, Eliz, Jones, Brendan C., de Wilton, Angus, Wilbrey-Clark, Anna, Sungnak, Waradon, Pett, J. Patrick, Weller, Juliane, Prigmore, Elena, Yung, Henry, Mehta, Puja, Saleh, Aarash, Saigal, Anita, Chu, Vivian, Cohen, Jonathan M., Cane, Clare, Iordanidou, Aikaterini, Shibuya, Soichi, Reuschl, Ann-Kathrin, Herczeg, Iván T., Argento, A. Christine, Wunderink, Richard G., Smith, Sean B., Poor, Taylor A., Gao, Catherine A., Dematte, Jane E., Reynolds, Gary, Haniffa, Muzlifah, Bowyer, Georgina S., Coates, Matthew, Clatworthy, Menna R., Calero-Nieto, Fernando J., Göttgens, Berthold, O’Callaghan, Christopher, Sebire, Neil J., Jolly, Clare, De Coppi, Paolo, Smith, Claire M., Misharin, Alexander V., Janes, Sam M., Teichmann, Sarah A., Nikolić, Marko Z., Meyer, Kerstin B.

期刊：Nature
发表时间：2021/12/22
数字识别码：10.1038/s41586-021-04345-x
摘要：It is not fully understood why COVID-19 is typically milder in children1,2,3. Here, to examine the differences between children and adults in their response to SARS-CoV-2 infection, we analysed paediatric and adult patients with COVID-19 as well as healthy control individuals (total n = 93) using single-cell multi-omic profiling of matched nasal, tracheal, bronchial and blood samples. In the airways of healthy paediatric individuals, we observed cells that were already in an interferon-activated state, which after SARS-CoV-2 infection was further induced especially in airway immune cells. We postulate that higher paediatric innate interferon responses restrict viral replication and disease progression. The systemic response in children was characterized by increases in naive lymphocytes and a depletion of natural killer cells, whereas, in adults, cytotoxic T cells and interferon-stimulated subpopulations were significantly increased. We provide evidence that dendritic cells initiate interferon signalling in early infection, and identify epithelial cell states associated with COVID-19 and age. Our matching nasal and blood data show a strong interferon response in the airways with the induction of systemic interferon-stimulated populations, which were substantially reduced in paediatric patients. Together, we provide several mechanisms that explain the milder clinical syndrome observed in children.

所属学科：
病毒学
（导读 郭怿暄）本研究利用单细胞组学对儿童和成人COVID-19患者和健康对照的鼻、气管、支气管和血液样品进行分析。发现健康儿童气道中已经有细胞处于干扰素激活状态，在感染SARS-CoV-2后会被进一步诱导。儿童更高的固有干扰素应答限制了病毒复制和疾病进展。儿童的系统性应答包括原始淋巴细胞增多和自然杀伤细胞减少，但成年人中细胞毒性T细胞和干扰素刺激的亚群显著增加。该结果为解释儿童中症状更轻提供机制。


文章标签
单细胞组学
COVID-19患者
儿童
成人
干扰素激活状态
原始淋巴细胞
自然杀伤细胞
细胞毒性T细胞

https://www.nature.com/articles/s41586-021-04345-x
自然  文章  文章
儿童和成人对 SARS-CoV-2 感染的局部和全身反应
发表：2021 年 12 月 22 日
儿童和成人对 SARS-CoV-2 感染的局部和全身反应
吉田正宏凯莉·B·沃洛克，…克斯汀·B·迈耶
自然
抽象的
尚未完全理解为什么COVID - 19在1、2、3岁儿童中通常较温和。在这里，为了检查儿童和成人对 SARS-CoV-2 感染的反应的差异，我们分析了 COVID-19 的儿科和成人患者以及健康对照个体（总n = 93) 使用匹配的鼻腔、气管、支气管和血液样本的单细胞多组学分析。在健康儿科个体的气道中，我们观察到已经处于干扰素激活状态的细胞，在 SARS-CoV-2 感染后被进一步诱导，尤其是在气道免疫细胞中。我们假设较高的儿科先天干扰素反应限制了病毒复制和疾病进展。儿童全身反应的特点是幼稚淋巴细胞增加和自然杀伤细胞减少，而在成人中，细胞毒性 T 细胞和干扰素刺激的亚群显着增加。我们提供的证据表明树突状细胞在感染早期启动干扰素信号传导，并确定与 COVID-19 和年龄相关的上皮细胞状态。我们匹配的鼻腔和血液数据显示气道中有强烈的干扰素反应，诱导全身干扰素刺激的人群，这在儿科患者中大大减少。我们一起提供了几种机制来解释在儿童中观察到的较轻微的临床综合征。

https://www.linkresearcher.com/t ... f-9c3e-edf101832756



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