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人类与病毒、细菌等微生物大决战之漫谈

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发表于 2022-4-25 10:18:14 | 显示全部楼层 |阅读模式
人类与病毒、细菌等微生物大决战之漫谈(传染病等关联的)

Hantao Gu
2021-9-19初稿(21.11.17 第一次修改、22.1.15第二次修改)

大约137亿年前起、我们所在的这个直径长达930亿左右光年的宇宙、从奇点开始大爆炸、逐步形成前子、电子、夸克、质子、中子、原子核、各种原子、元素、分子等。大约46亿年前起、太阳系和地球形成、并从大约38亿年前起开始了从有机化合物开始到最高生物我们人类为止的漫长的生物进化过程。大约自37亿年前起逐步进化出原核细胞(细菌等)、真核细胞(酵母菌、昆虫、我们人类、以及高等植物 等等)。并进化出了病毒。
病毒起源大致上有3类学说:
1)退化性起源学说。退化性起源学说认为病毒是细胞内寄生物的退化形式。
大约10-1亿年前起(或更早),可能是、有一些原核生物的细菌等等寄生物、进在宿主细胞中退化变异、丢弃了它绝大部分内容物,仅保留了脱氧核糖核酸(DNA),外面包上蛋白质,形成了病毒,在细菌等内(叫作噬菌体)和从酵母菌开始到我们人类为止的真核细胞中(叫作DNA病毒),过寄生生活、生长、繁殖、传播、传宗接代、延绵病毒种族。
2)病毒起源于宿主细胞中的RNA和(或)DNA成分的学说。
3)病毒起源于具有自主复制功能的原始大分子的学说,即病毒起源于自主复制的RNA分子。
我们人类与病毒、细菌、真菌等微生物之间的你死我活的战争由来已久、人类如此聪明能干、越战越勇、大多数能大获全胜、但有时偶尔也会大失败、就像约2019-12开始到今天22-1为止(还在行进中、还没有结束)的全球新冠病毒肺炎大流行、3.2亿多病人、550万多人死亡、飞机部分停飞、国界部分切断、前所未有的损害、人类大惨败!原因主要为各国抗疫不团结一致、科学性不够、资金、人员、物品等分配不佳等。现在、到本次大流行结束为止(可能还需要一年左右)、全世界要继续做好传染病预防治疗三大原则:1.管理(管控、隔离)传染源、2.切断传播途径、2.保护易感(弱体)人群、以及许多防治细节。
像本次2020新冠病毒肺炎等、自今年2021年起到2040年间大约20年内、可能还会有1-2次、全球大流行或世界某地区小流行。要预防(治疗)、用大决战战略!(敬请参阅:Hantao Gu 21.4.5 预测大约7年后的全世界下一次呼吸道病毒传染病 Facebook等网站连接  https://www.facebook.com/hantao.gu.75/posts/285101349885265  https://tieba.baidu.com/p/7286973296  http://www.kaseisyoji.com/forum. ... amp;extra=page%3D13
而且2021年到2220的2百年间、这种类似的传染病全世界大约还会有10-20次的大、小流行、更要用与微生物等的、更进一步的大决战战略、要大降、降到这2百年中仅1-2次、降约90%!这些需要有财力国家们出力出人、多学科的科学家们合作、努力、卫生医疗等国际组织协调、指导,等等。
现在我们人类是相当有智慧的、有知识、有经验教训、有经济条件即钱财物资以及人员、足已达到以上大决战战略目标、更科学有效、更切实本质地执行隔离切断保护传染病防治3大原则及细节。杀灭或减少有害微生物。更多地运用热力学、生物物理学、分子生物学、人工智能等科学力量。不断加强广谱疫苗研究。减少有害野生动物的数量和繁殖力。祝福人类!

(将来二百年间传染病等、要点词:
知识 简化 教育 专业 民众 重点教育
杀病毒剂、杀菌剂 高效低毒、气剂 气态吸入 氯化盐类 其他多种
管理 (管控、 隔离)
切断 停 (运、人流 避3密)
保护 暖、温、热力学、免疫、防疫、疫苗 广谱
野生动物 蝙蝠等等 管理 减少数量
预测 预警 计算机 人工智能 )

(顾汉涛随简漫谈  初稿于 21-9-19)
( 2021.11.17 第一次修改、22.1.15第二次修改、草案,将进一步增加、修改)
(2022.9.12.因我们微小团队缺人员、缺经费、无力再将本文编写下去、就此暂停、等以后具备条件时再继续写,对不起!也欢迎有志有识者、顺着我们的思路、继续研究、编写下去、为人类造福!)

建议阅读参考文献等(2022.4.25起逐步列入):

1.Nature:与新冠病毒 相关的蝙蝠冠状病毒及其对人体细胞的传染性
https://www.linkresearcher.com/t ... 2-bd1b-c0f48ee13658
Nature:Bat coronaviruses related to SARS-CoV-2 and infectious for human cells
https://www.nature.com/articles/s41586-022-04532-4
2.Nature子:Origin and evolution of pathogenic coronaviruses
(致病性冠状病毒的起源和进化)
https://www.nature.com/articles/s41579-018-0118-9.
3.Lessons from the host defences of bats, a unique viral reservoir
蝙蝠的宿主防御经验教训,一种独特的病毒库
https://www.nature.com/articles/ ... fJ0mlrAXmLWBHG2Pwfw
4.Science:Immunological characteristics govern the transition of COVID-19 to endemicity
https://www.science.org/doi/10.1126/science.abe6522
Science:新研究表明COVID-19(新冠病毒肺炎)很可能最终变成一种症状轻微的流行病  需1到10年
免疫学特征决定了 COVID-19 向地方病的转变  
http://news.bioon.com/article/6783078.html
5.Nature:FcγR-mediated SARS-CoV-2 infection of monocytes activates inflammation
https://www.nature.com/articles/s41586-022-04702-4
Nature:研究揭示新冠引发严重炎症机制,抗体治疗仅早期有效  
https://www.linkresearcher.com/t ... a2VG9qZBegKceeoVGDc
6.Natues:High-dimensional characterization of post-acute sequelae of COVID-19
(COVID-19 急性后遗症的高维表征)
https://www.nature.com/articles/ ... A4QberjxP4ileJcI_Q4
7.ERJ:Revisiting the association between temperature and COVID-19 transmissibility across 117 countries
重新审视 117 个国家的温度与 COVID-19 传播率之间的关联
https://openres.ersjournals.com/ ... _campaign=shareline
王辰院士:气温每上升1度可导致新冠肺炎发病率下降5.4%
https://www.sohu.com/a/433059861_359980
8.Temperature-dependent innate defense against the common cold virus limits viral replication at warm temperature in mouse airway cells
针对普通感冒病毒的温度依赖性先天防御限制了小鼠气道细胞在温暖温度下的病毒复制
https://www.pnas.org/doi/full/10.1073/pnas.1411030112
9.Variant-proof vaccines — invest now for the next pandemic
防变异疫苗——现在为下一次大流行投资
https://www.nature.com/articles/ ... 9ILYi9EcEIz88r7xpZ0
10.消毒剂使用指南
http://www.nhc.gov.cn/zhjcj/s914 ... 45c6a18e21dc2.shtml
参考文献等11~
Nature:新研究发现9种新的冠状病毒  超级计算机 早识别 隔切保
https://www.nature.com/articles/s41586-021-04332-2
https://news.bioon.com/article/6795350.html
https://www.linkresearcher.com/t ... c-85d6-b1cf7dd90008
Science:父母接种新冠疫苗也为儿童提供了实质性的保护
https://www.science.org/doi/10.1126/science.abm3087
https://news.bioon.com/article/6795329.html
新冠病毒会促进细胞衰老,从而导致长期后遗症的出现
https://www.nature.com/articles/s43587-022-00170-7
https://www.science.org/doi/10.1126/science.abe4832
https://www.nature.com/articles/s41586-021-03995-1
https://www.linkresearcher.com/t ... f-a39d-ea9b0e5defe9
自然医学: 新冠病毒长期影响心血管健康  损害
https://www.nature.com/articles/s41591-022-01689-3
https://www.nature.com/articles/d41586-022-00403-0
https://paper.sciencenet.cn/html ... 23183475369999.shtm
Science:探究新冠肺炎引起的一系列神经系统症状  长期后遗 脱髓鞘
https://www.science.org/doi/10.1126/science.abm2052
https://news.bioon.com/article/6795363.html
Science:科学家开发出一种抑制广谱sarbecoviruses感染的新型抗体 未来或有望帮助靶向作用SARS-CoV-2!
造广谱新型冠状病毒疫苗
https://www.science.org/doi/10.1126/science.abm8143
https://news.bioon.com/article/6795065.html
Science : Ecology and economics for pandemic prevention  
https://www.science.org/doi/10.1126/science.abc3189
Nature : Pandemic whistleblower: we need a non-political way to track viruses  
https://www.nature.com/articles/ ... OKkwZxolBiXjITdEfi8
综述  冠状病毒的特性及其致病性研究进展
http://rs.yiigle.com/CN115673201804/1060849.htm
Nature:美国首个转基因蚊子实验结果公布
https://www.nature.com/articles/d41586-022-01070-x
Cell-Med:“便中带毒”?新冠患者感染7个月后,粪便中仍存有病毒
https://www.sciencedirect.com/sc ... i/S2666634022001672
https://news.bioon.com/article/4743e2556839.html
Nature:气候变化增加了跨物种病毒传播  Climate change increases cross-species viral transmission risk
https://www.nature.com/articles/s41586-022-04788-w
https://paper.sciencenet.cn/html ... 21418444172455.shtm
Nature:遭受SARS-CoV-2感染的肺部巨噬细胞中的炎小体激活可导致新冠肺炎
https://www.nature.com/articles/s41586-022-04802-1
https://news.bioon.com/article/cf74e25759b0.html
Nature:免疫记忆提供对新冠病毒的长期保护
https://www.nature.com/articles/s41586-021-04280-x
https://news.bioon.com/article/6795498.html
Nature:在接种新冠疫苗后的几个月内,抗体的质量会改善
https://news.bioon.com/article/6796224.html
https://www.nature.com/articles/s41586-022-04527-1
提高呼吸道温度(以及体温) 防治新冠病毒肺炎十分重要
http://www.kaseisyoji.com/forum. ... &extra=page%3D7
https://www.facebook.com/hantao. ... jsi619DNYFNLy9o2idl
医学建议:使用气态吸入性杀病毒剂预防治疗新冠病毒肺炎
http://www.kaseisyoji.com/forum. ... &extra=page%3D7
https://www.facebook.com/hantao. ... Q5pwQvUrSb35sXAikol
研究随想  加强防治新冠保护人类避免退化
http://www.kaseisyoji.com/forum. ... &extra=page%3D6
https://www.facebook.com/hantao. ... QESPeQsoJu8v4ZzmTTl
Nature:Pathogen spillover driven by rapid changes in bat ecology
人类与病毒、细菌等微生物大决战之漫谈(传染病等关联的)
http://www.fuaaj.org/bbs/viewthr ... a=page%3D1#pid10750
http://www.kaseisyoji.com/forum. ... &extra=page%3D2
https://www.facebook.com/hantao. ... fK3bVRXUmUfGs6d7Y6l
《自然》:蝙蝠生境变化或促使人畜共患病毒的出现
https://www.nature.com/articles/s41586-022-05506-2
https://paper.sciencenet.cn/html ... 14143741577155.shtm
Science:Imprinted antibody responses against SARS-CoV-2 Omicron sublineages
https://www.science.org/doi/10.1126/science.adc9127
Science:针对新冠病毒奥密克戎变异株亚谱系的免疫印迹抗体反应
https://www.linkresearcher.com/t ... 2-80a6-02b4b804c4fc
Nature: A multinational Delphi consensus to end the COVID-19 public health threat
自然 : 结束 COVID-19 公共卫生威胁的多国德尔福共识
https://www.nature.com/articles/s41586-022-05398-2
Nature:Effect of the intratumoral microbiota on spatial and cellular heterogeneity in cancer
https://www.nature.com/articles/s41586-022-05435-0
Cell:The cancer chemotherapeutic 5-fluorouracil is a potent Fusobacterium nucleatum inhibitor and its activity is modified by intratumoral microbiota
https://www.cell.com/cell-report ... 66%3Fshowall%3Dtrue
1篇Nature+1篇Cell子刊揭示肿瘤内细菌有助肿瘤进展和抵抗治疗
https://news.bioon.com/article/4e4ce486449a.html
Science:Vaccination induces HIV broadly neutralizing antibody precursors in humans
https://www.science.org/doi/10.1126/science.add6502
《科学》:新型HIV疫苗使97%试验者产生HIV抗体
https://paper.sciencenet.cn/html ... 21355141777438.shtm
Nature:Selective inhibition of miRNA processing by a herpesvirus-encoded miRNA
https://www.nature.com/articles/s41586-022-04667-4
Nature:揭示人类疱疹病毒通过抑制宿主细胞microRNA产生而重新激活机制
https://news.bioon.com/article/c027e2753721.html
Cold exposure impairs extracellular vesicle swarm–mediated nasal antiviral immunity
https://www.sciencedirect.com/sc ... i/S0091674922014233
为什么新冠、流感都在冬天更流行?原来是鼻子里的免疫军团“冷到怠工”了!
https://news.bioon.com/article/d422e516955e.html
Nature:SARS-CoV-2 infection and persistence in the human body and brain at autopsy
(尸检时 SARS-CoV-2 感染和在人体和大脑中的持续存在)
https://www.nature.com/articles/s41586-022-05542-y
(SARS-CoV-2 infection and persistence throughout the human body and brain  
https://www.researchsquare.com/article/rs-1139035/v1  
尸检报告:新冠病毒遍布全身,包括大脑  
https://www.yxj.org.cn/detailPage?articleId=330119  
美国NIH:SARS-CoV-2能持续感染全身多个器官甚至大脑!  
https://m.ebiotrade.com/Newsf/2022-1/2022110143826549.htm
https://www.nature.com/articles/s41586-022-05542-y
Nature:震惊!我国科学家领衔揭示两种与MERS-CoV亲缘关系最接近的蝙蝠冠状病毒使用蝙蝠ACE2受体进入宿主细胞
https://news.bioon.com/article/f433e52493ee.html
Close relatives of MERS-CoV in bats use ACE2 as their functional receptors
https://www.nature.com/articles/s41586-022-05513-3
继续做好新冠病毒肺炎预防三大原则和各种细节(防日8波)
http://www.fuaaj.org/bbs/viewthr ... a=page%3D1#pid10766
http://www.kaseisyoji.com/forum. ... amp;extra=#pid96722
https://www.facebook.com/hantao. ... rbG3cS1C3v7fWEVW3Cl
Nature:谢晓亮/曹云龙破解新冠演化趋势,当前群体免疫和疫苗加强可能无法预防
https://news.bioon.com/article/a155e5289231.html
Nature:印迹 SARS-CoV-2 体液免疫诱导 Omicron RBD 趋同进化
https://www.nature.com/articles/s41586-022-05644-7
Nature:Broadly neutralizing antibodies overcome SARS-CoV-2 Omicron antigenic shift  
Nature:广泛中和抗体克服 SARS-CoV-2 Omicron 抗原转变
https://www.nature.com/articles/s41586-021-04386-2
Nature重磅综述:如果不采取行动,长新冠或会造成终身残疾
Nature reviews microbiology: Long COVID: major findings, mechanisms and recommendations
https://news.bioon.com/article/3a19e56434bd.html
https://www.nature.com/articles/s41579-022-00846-2
Nature medicine  Review Article : Unexplained post-acute infection syndromes
自然  自然医学  评论文章: 无法解释的急性感染后综合征
https://www.nature.com/articles/s41591-022-01810-6
Nature:揭示肠道和口腔微生物组的人际传播特征  垂直代际水平人际
Nature:The person-to-person transmission landscape of the gut and oral microbiomes
https://news.bioon.com/article/ff5fe56784e9.html
https://www.linkresearcher.com/t ... 5-8e58-363ae73e1fdc
https://www.nature.com/articles/s41586-022-05620-1
《自然》:刷新认知!科学家首次发现,肿瘤中的微生物不是随机分布的,而是高度组织化的  侵袭免抑
Nature:Effect of the intratumoral microbiota on spatial and cellular heterogeneity in cancer
https://news.bioon.com/article/2bc5e59222b3.html
https://www.nature.com/articles/s41586-022-05435-0
Nature:哈佛医学院团队发现流感信息由气道直达大脑的信号通路  迷走舌咽背根感觉
https://www.nature.com/articles/s41586-023-05796-0
https://news.bioon.com/article/7d09e62729a1.html
https://paper.sciencenet.cn/html ... 19345210379997.shtm
https://news.bioon.com/article/49a1e62298a6.html
http://www.kaseisyoji.com/forum. ... amp;extra=#pid96848
日本第9波の主流と予想されるオミクロン株「XBB系統」 現時点で分かっていること
https://news.yahoo.co.jp/byline/kutsunasatoshi/20230416-00345802
23-4-26顧预测23年夏新冠疫情建议防治
http://www.kaseisyoji.com/forum. ... id=82017&extra=
https://www.facebook.com/hantao. ... okbN16zksBeFEDvrDdl
http://www.fuaaj.org/bbs/viewthr ... e%3D1&frombbs=1
Nature:控制COVID-19可能需要定期接种加强疫苗
https://www.nature.com/articles/s41586-023-06025-4
https://news.bioon.com/article/6bd1e66356f2.html
http://www.kaseisyoji.com/forum. ... amp;extra=#pid96876
日本「新型コロナウイルス感染症対応記録」
http://www.jpha.or.jp/sub/topics/20230427_1.pdf
EB病毒感染了全世界90%的人,涉嫌多种癌症,《自然》新研究揭示它如何致癌
https://www.nature.com/articles/s41586-023-05923-x
https://www.linkresearcher.com/t ... 7-b06d-899f36fbd687
《科学·进展》:科学家首次发现,新冠病毒会导致神经元融合,严重损害神经活动
https://news.bioon.com/article/9fb9e780492b.html
SARS-CoV-2 infection and viral fusogens cause neuronal and glial fusion that compromises neuronal activity
https://www.science.org/doi/10.1126/sciadv.adg2248
Nature:新研究首次揭示为何一些感染新冠病毒的人从未出现症状
https://news.bioon.com/article/d32ce83293af.html
Nature:SARS-CoV-2 is associated with changes in brain structure in UK Biobank
https://www.nature.com/articles/s41586-022-04569-5
轻症也会损伤大脑!《自然》报道:新冠感染或导致脑部退行性病变
https://www.linkresearcher.com/t ... dQohLGbDQliltTEmC-s
nature:A common allele of HLA is associated with asymptomatic SARS-CoV-2 infection
https://www.nature.com/articles/s41586-023-06331-x
Nat Commun:体温升高会增加宿主身体对致病性病毒感染的抵抗力
https://news.bioon.com/article/a105e8468484.html
Nature communications:  High body temperature increases gut microbiota-dependent host resistance to influenza A virus and SARS-CoV-2 infection
https://www.nature.com/articles/s41467-023-39569-0
新しい変異株「BA.2.86系統」について現時点で分かっていること
https://news.yahoo.co.jp/expert/ ... 7cd09dfe6034c95063f
https://www.cdc.gov/respiratory- ... ate-2023-09-08.html
https://www.gov.uk/government/pu ... chnical-briefing-53
https://www.niid.go.jp/niid/ja/2 ... DYFLTL2uslnHenUmWyk
Nature:PLSCR1 是一种针对 SARS-CoV-2 感染的细胞自主防御因子
Nature: PLSCR1 is a cell-autonomous defence factor against SARS-CoV-2 infection
https://www.nature.com/articles/s41586-023-06322-y
Nature :新冠病毒奥密克戎变体的中和、效应子功能和免疫印记
https://www.linkresearcher.com/t ... a-9cb0-fee7afb49a91
Nature :Neutralization, effector function and immune imprinting of Omicron variants
https://www.nature.com/articles/s41586-023-06487-6
Nature:由莫诺拉韦引发的新冠病毒新突变,去年已在多国出现
https://www.linkresearcher.com/t ... c-a636-0d37bf558b02
Nature:A molnupiravir-associated mutational signature in global SARS-CoV-2 genomes
https://www.nature.com/articles/s41586-023-06649-6
Nature:揭示人类冠状病毒进入宿主细胞之谜 唾液酸聚糖
https://news.bioon.com/article/e2e3e961990b.html
Nature:Sialoglycan binding triggers spike opening in a human coronavirus
https://www.nature.com/articles/s41586-023-06599-z
Science 速递:多物种微生物群落共存是一种涌现现象
https://www.linkresearcher.com/t ... e-904d-f358c4a22615
Science: Emergent coexistence in multispecies microbial communities
https://www.science.org/doi/10.1126/science.adg0727
Science 速递:多物种微生物群落共存是一种涌现现象
多物种微生物群落中的新兴共存。竞争排斥是最常见的结果,许多物种无法在相同条件下成对共培养共存。
http://www.kaseisyoji.com/forum. ... &extra=page%3D2
Science:发现一系列针对 SARS-CoV-2的强效抗病毒氨基吡啶先导化合物
https://news.bioon.com/article/0b2b800385bc.html
Science:Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors
https://www.science.org/doi/10.1126/science.abo7201
《自然》:细菌cGAS感知病毒RNA启动免疫功能
https://paper.sciencenet.cn/html ... 20522441189825.shtm
Nature:Bacterial cGAS senses a viral RNA to initiate immunity
https://www.nature.com/articles/s41586-023-06743-9
http://www.kaseisyoji.com/forum. ... amp;extra=#pid96998
Nature | 病毒大流行的早期预警系统——EVEscape
https://www.linkresearcher.com/t ... 0-8368-e61c374f705e
Nature : Learning from prepandemic data to forecast viral escape
https://www.nature.com/articles/s41586-023-06617-0
科学内幕 新闻专题:新冠肺炎的冷表兄弟     四种很大程度上被忽视的冠状病毒在人类中传播,但没有造成巨大伤害,可能预示着 SARS-CoV-2 的未来 ?     2024 年 1 月 11 日东部时间上午 8:00乔恩·科恩
ScienceInsider  News Features : COVID’S COLD COUSINS     Four largely ignored coronaviruses circulate in humans without causing great harm and may portend the future for SARS-CoV-2 ?     11 JAN 20248:00 AM ETBYJON COHEN
https://www.science.org/content/ ... clues-covids-future
東京大学佐藤佳教授: SARS-CoV-2オミクロンJN.1株のウイルス学的特性の解明
https://www.ims.u-tokyo.ac.jp/im ... ess/page_00273.html
The Lancet Infectious Diseases : Virological characteristics of the SARS-CoV-2 JN.1 variant
https://www.thelancet.com/journa ... 23)00813-7/fulltext
JN.1株出現から見えてきた、大流行する変異株の共通点は?
https://wpb.shueisha.co.jp/news/technology/2024/01/13/121897/
日本理化学研究所、京都大学  「ポストコロナ」で警戒すべき心不全パンデミック
-SARS-CoV-2の持続感染は心不全リスクを高める可能性-
https://www.riken.jp/press/2023/20231223_1/index.html
Predicted risk of heart failure pandemic due to persistent SARS-CoV-2 infection using a three-dimensional cardiac model
https://www.sciencedirect.com/sc ... i/S2589004223027189
理研・京大の研究チームが発表―コロナ既感染 累計4千万人全員に心不全のリスク
https://news.yahoo.co.jp/article ... d42b0e47cd1e2ad9eb0
46岁网红麻醉师朱翔举办追悼会,妻儿悲痛欲绝,微信头像惹泪目
https://new.qq.com/rain/a/20240116A0004O00
Nature : 噬菌体通过多种抗防御蛋白质克服细菌免疫力
https://www.linkresearcher.com/t ... 7-bf51-dffeabe633bb
Nature : Phages overcome bacterial immunity via diverse anti-defence proteins
https://www.nature.com/articles/s41586-023-06869-w
Science:新研究揭示补体系统的持续激活会损害活动性长新冠患者体内的组织和血细胞
https://news.bioon.com/article/da5d81014811.html
Science:Persistent complement dysregulation with signs of thromboinflammation in active Long Covid
https://www.science.org/doi/10.1126/science.adg7942
Nat Neurosci:神经系统症状不是大脑感染SARS-CoV-2的直接结果
https://news.bioon.com/article/593281368eff.html
Nature: Proteomic and transcriptomic profiling of brainstem, cerebellum and olfactory tissues in early- and late-phase COVID-19
https://www.nature.com/articles/s41593-024-01573-y
Nature:新研究揭示细菌抗病毒防御系统 Thoeris的激活机制
https://news.bioon.com/article/001d81462351.html
Nature: Activation of Thoeris antiviral system via SIR2 effector filament assembly
https://www.nature.com/articles/s41586-024-07092-x
Cell:新研究发现肺部和大脑之间存在直接的沟通途径
https://news.bioon.com/article/94a481e85456.html
Cell: Biofilm exopolysaccharides alter sensory-neuron-mediated sickness during lung infection
https://www.cell.com/cell/abstra ... 96%3Fshowall%3Dtrue
Science Advances : 重度COVID-19诱导的抗血管紧张素II自身抗体与血压失调和疾病严重程度相关 Severe COVID-19 induces autoantibodies against angiotensin II that correlate with blood pressure dysregulation and disease severity
https://www.science.org/doi/10.1126/sciadv.abn3777
Science : 新冠病毒 《科学》杂志正在努力提供有关 COVID-19 及其冠状病毒的最佳、最及时的研究和分析。所有内容均可免费访问。新闻部对这一流行病的报道也是免费的,可以在这里单独找到。CORONAVIRUS   The Science journals are striving to provide the best and most timely research and analysis of COVID-19 and the coronavirus that causes it. All content is free to access. The News Department's coverage of the pandemic, also free, can be found separately here.
https://www.science.org/collecti ... 103&pageSize=20

建议阅读参考书目(大学教科书或大型参考书):
物理学、
化学、
生物学、
病毒学、
细菌学、
微生物学、
生理学、
病理学、
卫生学、
传染病学、
内科学 等等



 楼主| 发表于 2022-9-12 17:54:43 | 显示全部楼层
本帖最后由 顾汉现 于 2022-12-27 16:44 编辑

(Baidu English Translation: )

On the decisive battle between human beings and microorganisms such as viruses and bacteria

Hantao Gu
First draft on September 19, 2021 (revised for the first time on 21.11.17 and revised for the second time on 22.1.15 )

About 13.7 billion years ago, the universe in which we live has a diameter of 93 billion light years. The big bang started at the singularity and gradually formed the protons, electrons, quarks, protons, neutrons, atomic nuclei, various atoms, elements, molecules, etc. About 4.6 billion years ago, the formation of the solar system and the earth, and from about 3.8 billion years ago, began the long biological evolution process from organic compounds to the highest organism, our human beings. Since about 3.7 billion years ago, prokaryotic cells (bacteria, etc.) and eukaryotic cells (yeast, insects, our human beings, and higher plants, etc.) have evolved gradually. And evolved viruses.
There are three theories about the origin of viruses:
1) The theory of retrogressive origin. The theory of retrogressive origin holds that viruses are degenerated forms of intracellular parasites.
Since about 10-1 billion years ago (or earlier), there may be some parasites such as prokaryotic bacteria, which degenerate and mutate in the host cells and discard most of its contents. Only DNA is retained and protein is coated on the outside to form viruses. They live a parasitic life in bacteria (called bacteriophages) and eukaryotic cells from yeast to human beings (called DNA viruses) Growing, reproducing, spreading, inheriting and perpetuating the virus race.
2) The theory that viruses originate from RNA and/or DNA components in host cells.
3) The theory that viruses originate from primitive macromolecules with the function of autonomous replication, that is, viruses originate from RNA molecules with autonomous replication.

Our long-standing fight at outrance between human beings and viruses, bacteria and fungi has been so smart, capable, and gain a complete victory. Sometimes, however, it will fail like a global COVID-19 pneumonia pandemic, which is about 2019-12, and is still in progress (22-1). (3.2) more than more than 5 million 500 thousand patients die, some aircraft are grounded, and some parts of the aircraft are cut off. Unprecedented damage and human fiasco! The main reasons are the lack of unity in the fight against the epidemic, the lack of scientificity, and the poor distribution of funds, personnel and goods. Now, until the end of the pandemic (it may take about a year), the world should continue to do a good job in the prevention and treatment of infectious diseases: 1 2. Management (control and isolation) of infectious sources Cut off the route of transmission, 2 Protect vulnerable (vulnerable) populations and many prevention and control details.

Like this 2020 COVID-19 pneumonia, from 2021 this year to 2040 years about 20 years, there may be 1-2 times, a global pandemic or a small epidemic in some area of the world. We should prevent (treat) and use the strategy of decisive battle! (please refer to: Hantao Gu 21.4.5 predicts the world's next respiratory virus infectious disease in about 7 years, and Facebook and other websites https://www.facebook.com/hantao.gu.75/posts/285101349885265 https://tieba.baidu.com/p/7286973296 http://www.kaseisyoji.com/forum. ... amp;extra=page%3D13 )

There will be about 90-2% of the world's infectious diseases in 100-20 years, and it will be reduced by about 2221-2% in 2021-20 years! These require the contribution of countries with financial resources, the cooperation and efforts of multidisciplinary scientists, the coordination and guidance of international organizations such as health care, and so on.

Now we humans are quite intelligent, knowledgeable, experienced and have economic conditions, that is, money, materials and personnel. We have achieved the above strategic objectives of the great showdown, and implemented the three major principles and details of isolation, cut-off, protection and prevention of infectious diseases more scientifically and effectively. Kill or reduce harmful microorganisms. Make more use of scientific forces such as thermodynamics, biophysics, molecular biology and artificial intelligence. We will continue to strengthen research on broad-spectrum vaccines. Reduce the number and fecundity of harmful wild animals. Bless mankind!

(key words in the next 200 years:
Knowledge simplification education major public key education
Virus killing agent, bactericide, high efficiency and low toxicity, gaseous inhalation of chlorinated salts, and many others
Management (control, isolation)
Cut off and stop operation (avoid 3 density of passenger flow)
Protect warm, warm, thermodynamics, immunity, epidemic prevention and broad-spectrum vaccine
Reduce the number of wild bats and so on
Prediction and early warning computer artificial intelligence)

(Gu Hantao talks about the first draft with Jane on September 19, 21)
(the first modification on November 17, 2021, the second modification on January 15, 2022 and the draft will be further added and modified)
(2022.9.12. Due to the lack of staff and funds in our small team, we are unable to continue to write this article. We will suspend it and continue to write it when conditions permit. Sorry! We also welcome those who are ambitious and knowledgeable, follow our ideas, continue to research, write, and benefit mankind!)



(百度日本語訳:)

人間とウイルス、細菌などの微生物の大決戦の漫談

Hantao Gu
2021-9-19初稿(21.1.117第1回修正、22.1.15第2回修正)

約137億年前から、私たちがいるこの直径930億前後の光年に及ぶ宇宙は、特異点から大爆発を始め、前子、電子、クォーク、陽子、中性子、原子核、各種原子、元素、分子などを徐々に形成してきた。約46億年前から、太陽系と地球が形成され、約38億年前から有機化合物から最高生物である私たち人類までの長い生物進化の過程が始まった。約37億年前から原核細胞(細菌など)、真核細胞(酵母菌、昆虫、私たち人間、そして高等植物など)が徐々に進化してきた。そしてウイルスを進化させた。
ウイルスの起源には大体3種類の学説がある:
1)退化性起源説。退化性起源説はウイルスが細胞内寄生物の退化形態であると考えている。
約10-1億年前から(あるいはそれ以前から)、おそらく、いくつかの原核生物の細菌などの寄生物があり、宿主細胞に進入して退化変異し、そのほとんどの内容物を廃棄し、デオキシリボ核酸(DNA)だけを残し、外パンにタンパク質を加え、ウイルスを形成し、細菌など内(バクテリオファージと呼ばれる)と酵母菌から私たち人間までの真核細胞中(DNAウイルスと呼ばれる)、寄生生活、成長、繁殖、伝播、継代、延綿ウイルス種族。
2)ウイルスは宿主細胞中のRNAおよび(または)DNA成分から起源するという説。
3)ウイルスは自主複製機能を持つ原始的な高分子から起源し、すなわちウイルスは自主複製RNA分子から起源するという学説。

私たち人間とウイルス、細菌、真菌などの微生物との戦いは古くから行われてきた。人間はこんなに頭がよくて、戦えば戦うほど勇ましくなり、多くの人が全勝することができるが、時には大失敗をすることもある。前代未聞の損害、人類の大惨敗!原因は主に各国の抗疫が一致せず、科学性が足りず、資金、人員、物品などの分配が悪いなどである。今、今回の大流行が终わるまで(あと1年ぐらいかかるかもしれない)、世界中で伝染病予防治疗を継続する3つの原则:1.感染源、2.伝播経路、2を遮断する.易感(弱体)の人々を保護し、多くの予防と治療の細部を保護する。

今回の2020新型コロナウイルス肺炎などは、今年2021年から2040年までの約20年間、1-2回、世界的な大流行や世界のある地域で小流行する可能性がある。予防、大决戦戦略で!(関連項目:Hantao Gu 21.4.5約7年後の世界の次の呼吸器ウイルス伝染病Facebookなどのサイト接続を予測 https://www.facebook.com/hantao.gu.75/posts/285101349885265  https://tieba.baidu.com/p/7286973296 http://www.kaseisyoji.com/forum. ... amp;extra=page%3D13 )

そして2021年から2220年までの2百年間、このような伝染病は世界で約10-20回の大、小流行、さらに微生物などとの大決戦戦略を用い、大降下、この2百年のうち1-2回、約90%低下するだろう。これらは財力のある国たちが人を出して、多学科の科学者たちが協力して、努力して、衛生医療などの国際組織の協調、指導などが必要です。

現在、われわれ人類はかなり知恵があり、知識があり、経験と教訓があり、経済条件があるすなわち金銭物資と人員があり、以上の大決戦戦略目標を達成し、より科学的に有効で、より確実に本質的に隔離を実行し、伝染病の予防と治療の3つの原則と細部を保護している。有害微生物を殺したり減らしたりする。熱力学、生物物理学、分子生物学、人工知能などの科学力をより多く運用する。広域ワクチンの研究を絶えず強化する。有害な野生動物の数と繁殖力を減らす。人類を祝福する!

(将来二百年、要点語:
知識簡略化教育専門民衆重点教育
ウイルス除去剤、殺菌剤高効率低毒、ガスガスガス吸入塩化塩類その他多種
管理(管理、隔離)
切断停止(運、人の流れを3密に避ける)
保護暖、温、熱力学、免疫、防疫、ワクチンの広域スペクトル
野生動物コウモリなどの管理減少数
予測アラートコンピュータ人工知能)

(顧漢濤随簡漫談初稿は21-9-19)
(2021.11.17第1回修正、22.1.15第2回修正、草案、さらに追加、修正)
(2022.9.12.私たちの小さなチームは人員が足りない、経費が足りない、これ以上本文を書くことができない、これで一時停止して、後で条件が整ったら書き続けて、申し訳ありません!有識者も歓迎して、私たちの考え方に沿って、研究を続けて、編纂して、人類のために幸福を作ります!)


发表于 2023-8-3 18:35:19 | 显示全部楼层
本帖最后由 邓文龙 于 2023-8-10 09:57 编辑

备用贴,暂保留不用。

( 更多的建议阅读参考文献等,敬请阅读再下方的帖子(即下方的第二个帖子):建议阅读参考文献等(2022.4.25起逐步列入)(2。2023-8-3起)
建议阅读参考文献等(2022.4.25起逐步列入)(2。2023-8-3起): )

建议阅读参考文献等(2022.4.25起逐步列入)(2。2023-8-3起):

Nature:新研究首次揭示为何一些感染新冠病毒的人从未出现症状
https://news.bioon.com/article/d32ce83293af.html
nature:A common allele of HLA is associated with asymptomatic SARS-CoV-2 infection
https://www.nature.com/articles/s41586-023-06331-x

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