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不生癌不痴呆长命百岁 募金计划

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发表于 2020-1-21 13:16:05 | 显示全部楼层 |阅读模式
本帖最后由 邓文龙 于 2020-2-8 12:28 编辑

不生癌不痴呆长命百岁 募金计划

不生癌不痴呆长命百岁  日本东京大学医学部、中国复旦上海医学院 出身者 研究团队 募金计划

科学防癌、健康长寿规划总的目标 等等内容 2014-9-13 13:12 前后初次公开发布在互联网上,提出最低需持续研究的、3年计划约需3600万日元(约36万美元或216万人民币元) :

http://www.kaseisyoji.com/forum. ... &extra=page%3D1

http://www.kaseisyoji.com/forum. ... &extra=page%3D1

(2014年9月到2019年12月,未正式对外募金、提供银行帐号、微信号等)

2020年1月19日起,正式对外募金、提供 银行帐号(日元、美元、欧元、台币、港币、新元等):

三菱UFJ銀行 
上野中央支店
普通預金口座:0426049
トウキョウサンユウショウジ

微信号(人民币,微信转账):

guhanxian

募集募捐所得到的金额,全部使用于 不生癌、不痴呆、长命百岁  这3项计划。
募集募捐金接受监督监管。募捐满3600万日元,即起动 不生癌、不痴呆、长命百岁  3项计划的其中一项、造福人类、造福捐款人。捐款者或其家属将优先加入 不生癌、不痴呆、长命百岁  这3项计划、得到关照和优待。
盼望  政府、财团、大企业、慈善家 等等 多多支持、赞助,造福天下百姓。人类已有  不生癌不痴呆长命百岁  之学术能力五年以上,但因为经费不足和其他种种原因不能应用、推广、实施,实为可惜!   



医学研究组防治能力一览表:

http://www.kaseisyoji.com/forum. ... digest%26digest%3D1

不生癌 奔一百  ガンなし 百歳まで:

http://www.kaseisyoji.com/forum. ... &extra=page%3D1

欢迎阅览 不生癌不痴呆长命百岁 关联文章:

http://www.kaseisyoji.com/forum.php?mod=forumdisplay&fid=40

http://www.kaseisyoji.com/forum.php?mod=forumdisplay&fid=31



(不好意思,部分大陆地区可能看不到这些日本网页,敬请到海外、港台澳新马、日本、美加欧澳等 阅览)

 楼主| 发表于 2020-1-21 13:38:42 | 显示全部楼层
本帖最后由 顾汉现 于 2020-1-21 13:40 编辑

2020年1月19日到2020年1月21日间,共获3笔捐款:

2020年1月19日,  1000日元, 捐款人: 应捐款人要求,暂不公开。
2020年1月19日,10000日元, 捐款人: 应捐款人要求,暂不公开。
2020年1月21日,20000日元。 捐款人: 应捐款人要求,暂不公开。

合计:31000元。

非常谢谢捐款人!

发表于 2020-1-27 21:46:52 | 显示全部楼层
本帖最后由 邓文龙 于 2020-2-11 17:05 编辑

不生癌(一生中从不生癌、终生不生癌,并包括临床治癒后不复发) 参考文献:

1.Nature:重磅!新型抗癌药物或能让癌细胞处于永久休眠状态!
http://news.bioon.com/article/6725571.html
http://www.kaseisyoji.com/forum. ... amp;extra=#pid95262
组蛋白乙酰基转移酶KAT6A / B抑制剂诱导衰老并阻止肿瘤生长
Jonathan B. Baell, David J. Leaver, Stefan J. Hermans, et al. Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth. Nature (2018), DOI: 10.1038/s41586-018-0387-5
https://www.nature.com/articles/s41586-018-0387-5

2.Science:重大突破!揭示γδ T细胞检测癌症和感染新机制
http://news.bioon.com/article/6749093.html
http://www.kaseisyoji.com/forum. ... &extra=page%3D1
Sci:γδ T细胞检测癌症和感染 感应磷酸抗原 根除患病细胞
Marc Rigau et al. Butyrophilin 2A1 is essential for phosphoantigen reactivity by γδ T cells. Science, 2020, doi:10.1126/science.aay5516.
https://science.sciencemag.org/c ... /08/science.aay5516

3.Nature:脑瘤恶化伴随神经网络的重塑
http://news.bioon.com/article/6749777.html
http://www.kaseisyoji.com/forum. ... &extra=page%3D1
PIK3CA变体在神经胶质瘤形成过程中选择性启动脑活动亢进
PIK3CA variants selectively initiate brain hyperactivity during gliomagenesis
https://www.nature.com/articles/s41586-020-1952-2

4.Nature:科学家鉴别出引发儿童肾脏癌症的新型机制
http://news.bioon.com/article/6748696.html
http://www.kaseisyoji.com/forum. ... &extra=page%3D2
染色质读取器中的功能获得突变导致细胞命运受损
Wan, L., Chong, S., Xuan, F. et al. Impaired cell fate through gain-of-function mutations in a chromatin reader. Nature 577, 121–126 (2020) doi:10.1038/s41586-019-1842-7
https://www.nature.com/articles/s41586-019-1842-7

5.《科学》:儿童肾癌始于胚胎时期
http://paper.sciencenet.cn/htmlp ... 12501383454010.shtm
http://www.kaseisyoji.com/forum. ... &extra=page%3D2
肾母细胞瘤的胚胎前体
Embryonal precursors of Wilms tumor
Tim H. H. Coorens1, Taryn D. Treger1,2,3, Reem Al-Saadi4,5, Luiza Moore1,2, Maxine G. B. Tran6,7, Thomas J. Mitchell1,2,8, Suzanne Tugnait4, Christine Thevanesan4, Matthew D. Young1, Thomas R. W. Oliver1,2,9, Minou Oostveen4,5, Grace Collord1,2,3, Patrick S. Tarpey2, Alex Cagan1, Yvette Hooks1, Mark Brougham10, Ben C. Reynolds11, Giuseppe Barone5, John Anderson4,5, Mette Jorgensen5, G. A. Amos Burke2,3, Johannes Visser2, James C. Nicholson2,3, Naima Smeulders5, Imran Mushtaq5, Grant D. Stewart2,8, Peter J. Campbell1, David C. Wedge12,13, Iñigo Martincorena1, Dyanne Rampling5, Liz Hook2,9, Anne Y. Warren2,9, Nicholas Coleman2,9, Tanzina Chowdhury5, Neil Sebire4,5, Jarno Drost14, Kourosh Saeb-Parsy2,8, Michael R. Stratton1, Karin Straathof4,5, Kathy Pritchard-Jones4,5, Sam Behjati1,2,3,*
Science  06 Dec 2019: Vol. 366, Issue 6470, pp. 1247-1251
https://science.sciencemag.org/content/366/6470/1247

6.Nature:诊断乳腺癌 人工智能完胜人类专家!
http://news.bioon.com/article/6748708.html
http://www.kaseisyoji.com/forum. ... &extra=page%3D2
乳腺癌筛查AI系统的国际评估
McKinney, S.M., Sieniek, M., Godbole, V. et al. International evaluation of an AI system for breast cancer screening. Nature 577, 89–94 (2020) doi:10.1038/s41586-019-1799-6
https://www.nature.com/articles/s41586-019-1799-6

7.Nature:揭示摄入更多乳酸的黑色素瘤细胞是转移高手
http://news.bioon.com/article/6748361.html
http://www.kaseisyoji.com/forum. ... &extra=page%3D2
代谢异质性赋予黑色素瘤转移潜能差异
Alpaslan Tasdogan et al. Metabolic heterogeneity confers differences in melanoma metastatic potential. Nature, 2019, doi:10.1038/s41586-019-1847-2.
https://www.nature.com/articles/s41586-019-1847-2

8.Cell:染色体外非编码DNA促进神经胶质瘤发生
http://news.bioon.com/article/6747050.html
http://www.kaseisyoji.com/forum. ... id=95264&page=1
功能增强子塑造染色体外致癌基因扩增
Cell Volume 179, Issue 6, 27 November 2019, Pages 1330-1341.e13
Article   Functional Enhancers Shape Extrachromosomal Oncogene Amplifications
https://www.sciencedirect.com/sc ... 19312164?via%3Dihub

9.Nature:重磅!科学家成功揭示肿瘤中环状染色体外DNA的结构与功能
http://news.bioon.com/article/6747044.html
http://www.kaseisyoji.com/forum. ... &extra=page%3D3
环状ecDNA促进染色质的可及性和高癌基因表达
Wu, S., Turner, K.M., Nguyen, N. et al. Circular ecDNA promotes accessible chromatin and high oncogene expression. Nature (2019) doi:10.1038/s41586-019-1763-5
https://www.nature.com/articles/s41586-019-1763-5
染色体外致癌基因扩增驱动肿瘤进化和遗传异质性
Turner, K., Deshpande, V., Beyter, D. et al. Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity. Nature 543, 122–125 (2017) doi:10.1038/nature21356
https://www.nature.com/articles/nature21356

10.Nature等:揭示促进癌症扩散的生存技能!
http://news.bioon.com/article/6745675.html
http://www.kaseisyoji.com/forum. ... &extra=page%3D5
E-钙黏着蛋白是乳腺癌多种模型转移所必需的
Veena Padmanaban, Ilona Krol, Yasir Suhail, et al. E-cadherin is required for metastasis in multiple models of breast cancer, Nature (2019) doi:10.1038/s41586-019-1526-3
https://www.nature.com/articles/s41586-019-1526-3

11.Nature:重磅!揭示癌症中RNA改变的分子特征!
http://news.bioon.com/article/6750096.html
http://www.kaseisyoji.com/forum. ... id=80396&extra=
癌症中RNA改变的基因组基础
Calabrese, C., Davidson, N.R., Demircioğlu, D. et al. Genomic basis for RNA alterations in cancer. Nature 578, 129–136 (2020). doi:10.1038/s41586-020-1970-0
https://www.nature.com/articles/s41586-020-1970-0

12.Nature:首个系统性癌症基因组图谱问世——揭示癌细胞演化之谜
http://news.bioon.com/article/6750110.html
http://www.kaseisyoji.com/forum. ... amp;extra=#pid95281
2,658种癌症的进化史
The evolutionary history of 2,658 cancers, Nature (2020). DOI: 10.1038/s41586-019-1907-7 ,
https://www.nature.com/articles/s41586-019-1907-7

13.Cancer:植物来源药物可用于治疗头颈癌
http://news.bioon.com/article/6750171.html
http://www.kaseisyoji.com/forum. ... amp;extra=#pid95285
APG-157在口腔癌中的随机1期安慰剂对照试验表明,该药具有系统吸收作用,并对细胞因子和肿瘤相关微生物具有抑制作用
Saroj K. Basak et al, A randomized, phase 1, placebo‐controlled trial of APG‐157 in oral cancer demonstrates systemic absorption and an inhibitory effect on cytokines and tumor‐associated microbes, Cancer (2020). DOI: 10.1002/cncr.32644
https://www.ncbi.nlm.nih.gov/pubmed/32022261

14.Science:细胞间通讯如何导致白血病发生?
http://news.bioon.com/article/6750158.html
http://www.kaseisyoji.com/forum. ... amp;extra=#pid95286
科学家发现细胞之间的流氓通信如何导致白血病
Scientists discover how rogue communications between cells lead to leukemia
https://medicalxpress.com/news/2 ... cells-leukemia.html

15.Nature:重大进展!新研究揭示最常见的SF3B1基因突变如何导致癌症
http://news.bioon.com/article/6745227.html
http://www.kaseisyoji.com/forum. ... &extra=page%3D5
非典型BAF复合体的剪接破坏
Daichi Inoue et al. Spliceosomal disruption of the non-canonical BAF complex in cancer. Nature, 2019, doi:10.1038/s41586-019-1646-9.
https://www.nature.com/articles/s41586-019-1646-9

16.《细胞》:中国学者国际上率先揭示肝癌分子特征全景和个性化诊治新策略
https://www.thepaper.cn/newsDetail_forward_4629110
http://www.kaseisyoji.com/forum. ... &extra=page%3D6
https://www.cell.com/cell/fullte ... 37%3Fshowall%3Dtrue

17.Nature:真菌感染与胰腺癌发生之间的关系
http://news.bioon.com/article/6744684.html
http://www.kaseisyoji.com/forum. ... &extra=page%3D6
真菌菌群通过激活MBL促进胰腺癌发生
Berk Aykut, Smruti Pushalkar, Ruonan Chen, Qianhao Li, Raquel Abengozar, Jacqueline I. Kim, Sorin A. Shadaloey, Dongling Wu, Pamela Preiss, Narendra Verma, Yuqi Guo, Anjana Saxena, Mridula Vardhan, Brian Diskin, Wei Wang, Joshua Leinwand, Emma Kurz, Juan A. Kochen Rossi, Mautin Hundeyin, Constantinos Zambrinis, Xin Li, Deepak Saxena, George Miller. The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL. Nature, 2019; DOI: 10.1038/s41586-019-1608-2
https://www.nature.com/articles/s41586-019-1608-2

18.自然-化学:大肠杆菌素致癌机制获破解
http://paper.sciencenet.cn/htmlp ... 61455554152675.shtm
http://www.kaseisyoji.com/forum. ... &extra=page%3D6
大环大肠菌素通过铜介导的氧化裂解诱导DNA双链断裂
https://www.nature.com/articles/s41557-019-0317-7

19.Science重大进展:科学家们发现肿瘤形成的原子驱动力
http://news.bioon.com/article/6742449.html
http://www.kaseisyoji.com/forum. ... &extra=page%3D8
Mengzhao Xue et al. Structure elucidation of colibactin and its DNA cross-links, Science (2019). DOI: 10.1126/science.aax2685
http://science.sciencemag.org/lookup/doi/10.1126/science.aax2685

20.Nature:重磅!癌症新伎俩!癌细胞产生更多的Win,并让邻近的健康细胞产生更多的Lose,促进癌症生长
http://news.bioon.com/article/6741757.html
http://www.kaseisyoji.com/forum. ... &extra=page%3D8
花同工型促进癌症的竞争性增长
Esha Madan et al. Flower isoforms promote competitive growth in cancer. Nature, 2019, doi:10.1038/s41586-019-1429-3.
https://www.nature.com/articles/s41586-019-1429-3

21.Nature:蛋白过度表达可能是癌细胞的致命弱点
http://news.bioon.com/article/6741706.html
http://www.kaseisyoji.com/forum. ... &extra=page%3D8
Hung-Ji Tsai et al. Hypo-osmotic-like stress underlies general cellular defects of aneuploidy, Nature (2019). DOI: 10.1038/s41586-019-1187-2
https://www.nature.com/articles/s41586-019-1187-2

22.Science:打破传统!癌症基因组中的突变“热点”不一定会推动癌症的生长!
http://news.bioon.com/article/6740678.html
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D10
Michael S. Lawrence et al. Passenger hotspot mutations in cancer driven by APOBEC3A and mesoscale genomic features. Science (2019). DOI: 10.1126/science.aaw2872
https://science.sciencemag.org/content/364/6447/eaaw2872

23.Nature:科学家有望实现让疲惫不堪的免疫细胞重新焕发活力 再次高效抑制癌症进展
http://news.bioon.com/article/6740600.html
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D10
Omar Khan, Josephine R. Giles, Sierra McDonald, et al. TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion, Nature (2019). DOI:10.1038/s41586-019-1325-x
https://www.nature.com/articles/s41586-019-1325-x

24.Science:重大突破!以前仅作为一种疾病生物标志物,如今发现CA19-9导致胰腺炎和胰腺癌产生
http://news.bioon.com/article/6740364.html
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D10
D.D. Engle el al.The glycan CA19-9 promotes pancreatitis and pancreatic cancer in mice. Science, 2019, doi:10.1126/science.aaw3145.
https://science.sciencemag.org/content/364/6446/1156
C.J. Halbrook el al. Hiding in plain sight. Science, 2019, doi:10.1126/science.aax9341.
https://science.sciencemag.org/content/364/6446/1132

25.Nature:挑战常规!FOXA1以三种不同方式化身为癌基因,促进癌症产生
http://news.bioon.com/article/6740393.html
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D10
Abhijit Parolia et al. Distinct structural classes of activating FOXA1 alterations in advanced prostate cancer. Nature, 2019, doi:10.1038/s41586-019-1347-4.
https://www.nature.com/articles/s41586-019-1347-4

26.Nature:中国科学家揭示尿苷二磷酸葡萄糖抑制肺癌转移  糖醛酸代谢中间物
http://news.bioon.com/article/6740376.html
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D10
Xiongjun Wang et al. UDP-glucose accelerates SNAI1 mRNA decay and impairs lung cancer metastasis. Nature, 2019, doi:10.1038/s41586-019-1340-y.
https://www.nature.com/articles/s41586-019-1340-y

27.《自然》:科学家揭示乳腺癌细胞转移机制  有望为预防癌症复发提供新法
http://paper.sciencenet.cn/htmlp ... 10305854552422.shtm
http://www.kaseisyoji.com/forum. ... &extra=page%3D7
E-cadherin is required for metastasis in multiple models of breast cancer
https://www.nature.com/articles/s41586-019-1526-3

28.Nat Commun:揭示癌细胞转移的最佳路径
http://news.bioon.com/article/6744136.html
http://www.kaseisyoji.com/forum. ... &extra=page%3D7
Matthew R. Zanotelli et al. Energetic costs regulated by cell mechanics and confinement are predictive of migration path during decision-making, Nature Communications (2019). DOI: 10.1038/s41467-019-12155-z
https://www.nature.com/articles/s41467-019-12155-z

29.Science:打破传统!癌症基因组中的突变“热点”不一定会推动癌症的生长!
http://news.bioon.com/article/6740678.html
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D10
Michael S. Lawrence et al. Passenger hotspot mutations in cancer driven by APOBEC3A and mesoscale genomic features. Science (2019). DOI: 10.1126/science.aaw2872
https://science.sciencemag.org/content/364/6447/eaaw2872

30.Nature:重磅!科学家成功解析出转移性乳腺癌的基因组特性!
http://news.bioon.com/article/6739034.html
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D12
Francois Bertucci, Charlotte K. Y. Ng, Anne Patsouris, et al,. Genomic characterization of metastatic breast cancers, Nature 569, 560–564 (2019) doi:10.1038/s41586-019-1056-z
https://www.nature.com/articles/s41586-019-1056-z

31.Cell:新研究揭示抗感染与抗癌症的新机制
http://news.bioon.com/article/6738965.html
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D13
Weina Zhang et al, Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS, Cell (2019). DOI: 10.1016/j.cell.2019.05.003
https://www.sciencedirect.com/sc ... 1930501X?via%3Dihub

32.Nature:来自中枢神经系统的神经祖细胞促进癌症中的神经发生
http://news.bioon.com/article/6738819.html
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D13
Philippe Mauffrey et al. Progenitors from the central nervous system drive neurogenesis in cancer. Nature, 2019, doi:10.1038/s41586-019-1219-y.
https://www.nature.com/articles/s41586-019-1219-y

33.Nature:科学家锁定癌症相关蛋白质,有望延缓癌症进展
http://ctxy.bioon.com/xy/article_pc.html?id=6738594
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D13
Dmitry I. Gabrilovich et al. Fatty acid transporter 2 reprograms neutrophils in cancer, Nature (2019). DOI: 10.1038/s41586-019-1118-2
https://www.nature.com/articles/s41586-019-1118-2

34.Nature:糖皮质激素促进乳腺癌转移
http://news.bioon.com/article/6735356.html
http://www.kaseisyoji.com/forum. ... amp;extra=#pid94539
Milan M. S. Obradović et al. Glucocorticoids promote breast cancer metastasis. Nature, 2019, doi:10.1038/s41586-019-1019-4.
https://www.nature.com/articles/s41586-019-1019-4

35.Nature:科学家成功揭示癌症的代谢成瘾特性
http://news.bioon.com/article/6737526.html
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D16
Sudhir Chowdhry, Ciro Zanca, Utkrisht Rajkumar, et al. NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodelling, Nature (2019). DOI: 10.1038/s41586-019-1150-2
https://www.nature.com/articles/s41586-019-1150-2

36.欧洲癌症杂志:哪些生活习惯会致癌? 胖晒病毒宫口肛癌
http://ctxy.bioon.com/xy/article_pc.html?id=6721281
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D16

37.Cell:大规模乳腺癌细胞组成分析带来新型治疗方法
http://ctxy.bioon.com/xy/article_pc.html?id=6737368
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D16
Johanna Wagner et al, A Single-Cell Atlas of the Tumor and Immune Ecosystem of Human Breast Cancer, Cell (2019). DOI: 10.1016/j.cell.2019.03.005
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38.Cell:通过构建胰腺癌干细胞分子依赖性图谱,揭示胰腺癌治疗新策略
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39.《自然》:面对癌症之王 中美科学家们联合找到了诊疗新思路
http://news.bioon.com/article/6737168.html
http://www.kaseisyoji.com/forum. ... amp;extra=page%3D16


发表于 7 天前 | 显示全部楼层
本帖最后由 邓文龙 于 2020-2-16 12:18 编辑

不生癌(一生中从不生癌、终生不生癌,并包括临床治癒后不复发) 参考文献 2 :

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41.Nature:大规模CRISPR/Cas9筛选鉴定出600个癌症基因靶标
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43.Nature:靶向胰腺癌致命弱点取得令人鼓舞的结果
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44.Science:揭示肿瘤抑制基因BAP1失活为何仅促进肿瘤在特定组织中形成
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45.Cell:新研究表明细菌可促进肺肿瘤产生
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46.Nature:发现p38γ是肝癌的一个新的治疗靶标
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47.《细胞》:科学家确认癌细胞可“远程缴械”免疫系统
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相关论文信息:DOI:https://doi.org/10.1016/j.cell.2019.02.016
https://www.cell.com/cell/fulltext/S0092-8674(19)30165-5#

48.Nature:解析特殊代谢酶的3D结构 有望帮助开发新型癌症疗法
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49.Nature:研究发现各种癌症组织中广泛存在的致癌组蛋白!
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50.一半癌症里都有它!科学家找到一种抗癌新策略  p53
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53.Nature:揭示乳腺癌细胞转移新机制
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54.Nature:新研究揭示为何癌症最常扩散到肝脏
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56.《自然》:中国科学家发现肝细胞癌精准治疗潜在新靶点
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58.Science:癌细胞通过增加核糖体蛋白产生来促进乳腺癌转移
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各种大型专著等:
现代肿瘤学
肿瘤学 新理论与新技术
临床用药指南
临床用药手册
治療薬マニュアル(治疗药物手册)
临床用药的药理学基础
新编药物学
药师手册
常用药物新用途临床大全
神经药理学
精神药理学
现代中药药理手册
中药抗肿瘤有效成分药理与应用
中药大辞典
实用内科学
诸福堂实用儿科学
中华妇产科学
眼科全书
临床皮肤科学
標準外科学
清华译 生物学
血液分子细胞生物学
医用微生物学
医用生物化学
人体生理学
体温生理学
病理学
神经科学
神经内分泌学
神经科学百科全书
睡眠医学 理论与实践
实用医学大辞典
实用营养学
特殊营养学
实用延年益寿学
衰老与老年病防治研究
现代穴位疗法大全
理科年表
诺贝尔奖获奖者全书

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