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PNAS:寒冷有助于癌细胞生长 T细胞抑

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发表于 2021-7-28 17:16:02 | 显示全部楼层 |阅读模式
本帖最后由 顾汉现 于 2021-7-28 17:18 编辑

PNAS:寒冷有助于癌细胞生长

来源:生物谷 2013-11-19 20:51

低温能够改变癌细胞的生长和扩散的方式。该研究对癌症治疗和癌症基础研究都有重要意义。

2013年11月19日讯 /生物谷BIOON/--低温会让机体进入应激状态,机体要提高代谢率以维持体温。持续低温会让细胞不能正常工作。近期发表在PNAS杂志上的文章称罗兹韦尔帕克癌症研究中心Elizabeth Repasky博士研究组又发现了一个低温的害处:低温能够改变癌细胞的生长和扩散的方式。该研究对癌症治疗和癌症基础研究都有重要意义。

Repasky博士发现生活在相对低温(22℃)的小鼠比生活在适宜温度(30℃)的小鼠癌细胞生长会更快,更有侵略性。寒冷环境会增加多种类型肿瘤的生长速度,如乳腺癌,皮肤癌,结肠癌,胰腺癌等。

而小鼠在患癌症之前的环境对癌症发展进程没有影响。在癌症形成后,寒冷才会让癌细胞生长更快。

机体主要通过T细胞来识别并摧毁癌细胞。而癌细胞会通过产生抑制T细胞的信号来对抗T细胞的攻击。这个战役将抑制持续下去,直到一方胜利。临床上很多的抗癌疗法都是让战役朝着对免疫系统有利的方向进行。

寒冷和温度舒适的小鼠有相同数量的攻击癌细胞的T细胞。但是温度舒适环境的小鼠体内的T细胞寻找癌细胞能力更强,攻击性也更好。T细胞分泌抗癌物质也更多。

而寒冷环境的小鼠体内有更多的抑制免疫反应的细胞,寒冷环境会让机体适应肿瘤而不是攻击肿瘤。(生物谷Bioon.com)

doi: 10.1073/pnas.1304291110

PMC:
PMID:

Baseline tumor growth and immune control in laboratory mice are significantly influenced by subthermoneutral housing temperature

Baseline tumor growth and immune control in laboratory mice are significantly influenced by subthermoneutral housing temperature

We show here that fundamental aspects of antitumor immunity in mice are significantly influenced by ambient housing temperature. Standard housing temperature for laboratory mice in research facilities is mandated to be between 20–26 °C; however, these subthermoneutral temperatures cause mild chronic cold stress, activating thermogenesis to maintain normal body temperature. When stress is alleviated by housing at thermoneutral ambient temperature (30–31 °C), we observe a striking reduction in tumor formation, growth rate and metastasis. This improved control of tumor growth is dependent upon the adaptive immune system. We observe significantly increased numbers of antigen-specific CD8+ T lymphocytes and CD8+ T cells with an activated phenotype in the tumor microenvironment at thermoneutrality. At the same time there is a significant reduction in numbers of immunosuppressive MDSCs and regulatory T lymphocytes. Notably, in temperature preference studies, tumor-bearing mice select a higher ambient temperature than non-tumor-bearing mice, suggesting that tumor-bearing mice experience a greater degree of cold-stress. Overall, our data raise the hypothesis that suppression of antitumor immunity is an outcome of cold stress-induced thermogenesis. Therefore, the common approach of studying immunity against tumors in mice housed only at standard room temperature may be limiting our understanding of the full potential of the antitumor immune response.

https://www.pnas.org/content/ear ... qNtZGzNAfijcnBszQji

https://news.bioon.com/article/6637307.html



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