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Nat:灵长类动物大脑抑制性神经元的发育与演化 猕猴和小鼠

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发表于 2022-5-6 16:08:30 | 显示全部楼层 |阅读模式
本帖最后由 顾汉现 于 2022-5-6 16:54 编辑

Nature:灵长类动物大脑抑制性神经元的发育与演化

灵长类大脑抑制性神经元的发育与进化。猕猴和小鼠。 GABA 多巴胺 神经肽、乙酰胆碱等递质受体。额叶白质神经元的异常积累与精神分裂症和自闭症相关, 由于它们长时间迁移到遥远且不断变化的目的地。

领研网

2022/04/11
论文
论文标题:The development and evolution of inhibitory neurons in primate cerebrum
作者:Schmitz, Matthew T., Sandoval, Kadellyn, Chen, Christopher P., Mostajo-Radji, Mohammed A., Seeley, William W., Nowakowski, Tomasz J., Ye, Chun Jimmie, Paredes, Mercedes F., Pollen, Alex A.

期刊:Nature
发表时间:2022/03/23
数字识别码:10.1038/s41586-022-04510-w
摘要:Neuroanatomists have long speculated that expanded primate brains contain an increased morphological diversity of inhibitory neurons (INs)1, and recent studies have identified primate-specific neuronal populations at the molecular level2. However, we know little about the developmental mechanisms that specify evolutionarily novel cell types in the brain. Here, we reconstruct gene expression trajectories specifying INs generated throughout the neurogenic period in macaques and mice by analysing the transcriptomes of 250,181 cells. We find that the initial classes of INs generated prenatally are largely conserved among mammals. Nonetheless, we identify two contrasting developmental mechanisms for specifying evolutionarily novel cell types during prenatal development. First, we show that recently identified primate-specific TAC3 striatal INs are specified by a unique transcriptional programme in progenitors followed by induction of a distinct suite of neuropeptides and neurotransmitter receptors in new-born neurons. Second, we find that multiple classes of transcriptionally conserved olfactory bulb (OB)-bound precursors are redirected to expanded primate white matter and striatum. These classes include a novel peristriatal class of striatum laureatum neurons that resemble dopaminergic periglomerular cells of the OB. We propose an evolutionary model in which conserved initial classes of neurons supplying the smaller primate OB are reused in the enlarged striatum and cortex. Together, our results provide a unified developmental taxonomy of initial classes of mammalian INs and reveal multiple developmental mechanisms for neural cell type evolution.

所属学科:
神经科学
(导读 阿金)目前对于灵长类动物大脑内特异于新细胞类型演化的机制知之甚少。本研究分析了250181个细胞转录组,重构了贯穿神经发生期间的抑制性神经元(INs)特化基因表达的轨迹,发现哺乳动物中最初胎盘生成的INs类型大部分为保守型。研究人员识别出两种相对的发育机制,可在胎盘发育过程中促进新细胞类型的特异性演化。该结果为哺乳动物最初的INs类型提供统一的发育分类学。

文章标签
灵长类动物
细胞转录组
神经发生
抑制性神经元
细胞类型、

https://www.nature.com/articles/s41586-022-04510-w

https://www.linkresearcher.com/t ... 3-981b-fc12e38346eb

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